Super-telomeres in transformed human fibroblasts
نویسندگان
چکیده
منابع مشابه
A mitogenic factor for transformed fibroblasts from human platelets.
Human platelets contain discrete glycoproteins that promote the growth of 3T3 (platelet-derived growth factor 1) and SV3T3 (platelet-derived growth factor 2) cells. The factor that promotes the growth of SV3T3 cells is a heat-labile nondialyzable glycoprotein with an isoelectric point of 7.8 to 8.3.
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Incubation of SV,,-transformed human lung fibroblasts with [“Hlglucosamine for 1 h, followed by chloroform:methanol extraction and thin layer chromatographic analysis, revealed the presence of a major radioactive lipid that was isolated and characterized as GlcUA-(1 + 4)GlcNAc-P-P-dolichol. An identical lipid was formed in smaller quantities under similar incubation conditions in several fibrob...
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Puromycin aminonucleoside arrests cultured normal hu man lung fibroblasts in the G, and G2 phases of the cell cycle but permits fibroblasts transformed by the oncogenic virus SV40 to continue their cell-cycle traverse. Amino nucleoside has no detectable effect on the entry of the transformed cells into mitosis but it does accelerate the rate of detachment of these cells from the growth surface....
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BACKGROUND When mosquitoes infected with DENV are feeding, the proboscis must traverse the epidermis several times ("probing") before reaching a blood vessel in the dermis. During this process, the salivary glands release the virus, which is likely to interact first with cells of the various epidermal and dermal layers, cells which could be physiologically relevant to DENV infection and replica...
متن کاملSV40 T-antigen is required for maintenance of immortal growth in SV40-transformed human fibroblasts.
Two lines of immortal human fibroblasts were isolated following transfection of TIG-3 cells with plasmid DNA, pMT-1ODtsA, that contained SV40 early gene with a deletion in replication origin and ts mutation in coding sequence for T-antigen. These cells continued proliferation at 34 degrees C, over 565 population doubling level (PDL) which is far over the limited division potential of untransfor...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
سال: 2013
ISSN: 0167-4889
DOI: 10.1016/j.bbamcr.2013.03.030